Article
Multifunctional cells in human pituitary adenomas: implications for paradoxical secretion and tumorigenesis.
The Journal of clinical endocrinology and metabolism - 1 Sept 2004
Senovilla Laura, Núñez Lucía, de Campos José M, de Luis Daniel A, Romero Enrique, Sánchez Ana, García-Sancho Javier, Villalobos Carlos
Abstract excerpt
Pituitary adenomas are very common in humans. They are of monoclonal origin, very heterogeneous, and produce frequently paradoxical secretion. The normal anterior pituitary (AP) contains some unorthodox multifunctional cells able to store more than one AP hormone (polyhormonal) and/or to express multiple hypothalamic-releasing hormone receptors (multiresponsive). Multifunctional AP cells seem to be involved in...
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