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Article

WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding.

Molecular cell - 10 Sept 2004

Lee Byung-Hoon, Min Xiaoshan, Heise Charles J, Xu Bing-E, Chen She, Shu Hongjun, Luby-Phelps Kate, Goldsmith Elizabeth J, Cobb Melanie H

Abstract excerpt

WNK (with no lysine [K]) protein kinases were named for their unique active site organization. Mutations in WNK1 and WNK4 cause a familial form of hypertension by undefined mechanisms. Here, we report that WNK1 selectively binds to and phosphorylates synaptotagmin 2 (Syt2) within its calcium binding C2 domains. Endogenous WNK1 and Syt2 coimmunoprecipitate and colocalize on a subset of secretory granules in INS-1...

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Source

Identifiers

PMID: 15350218
DOI: 10.1016/j.molcel.2004.07.018

Genes

WNK1
INS
WNK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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