[2,4-Dienoyl-CoA reductases: from discovery toward pathophysiological significance].

Abstract excerpt

2,4-Dienoyl-CoA reductases from Escherichia coli and bovine liver were purified and characterized by the authors and almost simultaneously by Kunau and his colleagues around the early 1980s. The authors purified 2,4-dienoyl-CoA reductase from rat liver, cloned its cDNA and expressed its active form in Escherichia coli for the first time. Schulz and his colleagues have elaborately shown that mutant E. coli, in...

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