Different mechanisms of regioselection of fatty acid hydroxylation by laurate (omega-1)-hydroxylating P450s, P450 2C2 and P450 2E1.

doi:10.1093/oxfordjournals.jbchem.a124339

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Article

Different mechanisms of regioselection of fatty acid hydroxylation by laurate (omega-1)-hydroxylating P450s, P450 2C2 and P450 2E1.

Journal of biochemistry - 1 Feb 1994

Fukuda T, Imai Y, Komori M, Nakamura M, Kusunose E, Satouchi K, Kusunose M

Abstract excerpt

P450 2C2 as well as P450 2E1 [Fukuda, T. et al. (1993) J. Biochem. 113, 7-12] catalyzed the hydroxylation of medium chain fatty acids, although the regioselectivity of substrates of the former contrasted with that of the latter. Whereas P450 2E1 hydroxylated C9-C18 fatty acids at the omega-1 posi...

Topics

Animals
Chromatography, High Pressure Liquid
Cytochrome P-450 CYP2E1
Cytochrome P-450 Enzyme System
Fatty Acids
Hydroxylation
Laurates
Mass Spectrometry
Mutation
Oxidoreductases, N-Demethylating
Rabbits
Substrate Specificity

Source

Open in PubMed

Identifiers

PMID: 8206883
DOI: 10.1093/oxfordjournals.jbchem.a124339

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8206883-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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