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Article

Distinct roles of endoplasmic reticulum cytochrome b5 and fused cytochrome b5-like domain for rat Delta6-desaturase activity.

Journal of lipid research - 1 Jan 2004

Guillou Hervé, D'Andrea Sabine, Rioux Vincent, Barnouin Romain, Dalaine Stéphanie, Pedrono Frédérique, Jan Sophie, Legrand Philippe

Abstract excerpt

The Delta6-desaturase catalyzes key steps in long-chain polyunsaturated fatty acid biosynthesis. Although the gene coding for this enzyme has been isolated in diverse animal species, the protein structure remains poorly characterized. In this work, rat Delta6-desaturase expressed in COS-7 cells was shown to localize in the endoplasmic reticulum. As the enzyme contains an N-terminal cytochrome b5-like domain, we...

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Source

Identifiers

PMID: 14563830
DOI: 10.1194/jlr.M300339-JLR200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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