Article
Mutations in the IGF-II pathway that confer resistance to lytic reovirus infection.
BMC cell biology - 27 Aug 2004
Sheng Jinsong, Organ Edward L, Hao Chuanming, Wells K Sam, Ruley H Earl, Rubin Donald H
Abstract excerpt
BACKGROUND: Viruses are obligate intracellular parasites and rely upon the host cell for different steps in their life cycles. The characterization of cellular genes required for virus infection and/or cell killing will be essential for understanding viral life cycles, and may provide cellular targets for new antiviral therapies. RESULTS: A gene entrapment approach was used to identify candidate cellular genes...
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