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Article

Detection of JC Virus-Specific Cytotoxic T Lymphocytes in Healthy Individuals

26 Aug 2004

Abstract excerpt

The polyomavirus JC (JCV) infects 85% of healthy individuals, and its reactivation in a limited number of immunosuppressed people causes progressive multifocal leukoencephalopathy (PML), a severe demyelinating disease of the central nervous system. We hypothesized that JCV-specific cytotoxic T lymphocytes (CTLs) might control JCV replication in healthy individuals, blocking the evolution of PML. Using 51Cr...

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PMID: 15331755
DOI: 10.1128/jvi.78.18.10206-10210.2004

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