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Article

Cyclic GMP-dependent protein kinase EGL-4 controls body size and lifespan in C elegans.

Development (Cambridge, England) - 1 Mar 2003

Hirose Takashi, Nakano Yoshiya, Nagamatsu Yasuko, Misumi Takashi, Ohta Hiromitsu, Ohshima Yasumi

Abstract excerpt

We designed an automatic system to measure body length, diameters and volume of a C. elegans worm. By using this system, mutants with an increased body volume exceeding 50% were isolated. Four of them are grossly normal in morphology and development, grow longer to be almost twice as big, and have weak egg-laying defects and extended lifespan. All the four mutants have a mutation in the egl-4 gene. We show that...

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PMID: 12571101
DOI: 10.1242/dev.00330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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