Article
Oligomycin induces a decrease in the cellular content of a pathogenic mutation in the human mitochondrial ATPase 6 gene.
The Journal of biological chemistry - 2 Apr 1999
Manfredi G, Gupta N, Vazquez-Memije M E, Sadlock J E, Spinazzola A, De Vivo D C, Schon E A
Abstract excerpt
A T --> G mutation at position 8993 in human mitochondrial DNA is associated with the syndrome neuropathy, ataxia, and retinitis pigmentosa and with a maternally inherited form of Leigh's syndrome. The mutation substitutes an arginine for a leucine at amino acid position 156 in ATPase 6, a component of the F0 portion of the mitochondrial ATP synthase complex. Fibroblasts harboring high levels of the T8993G...
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