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Article

Reduced expression of p27 is a novel mechanism of docetaxel resistance in breast cancer cells

5 Aug 2004

Abstract excerpt

INTRODUCTION: Docetaxel is one of the most effective chemotherapeutic agents in the treatment of breast cancer. Breast cancers can have an inherent or acquired resistance to docetaxel but the causes of this resistance remain unclear. However, apoptosis and cell cycle regulation are key mechanisms by which most chemotherapeutic agents exert their cytotoxic effects. METHODS: We created two docetaxel-resistant human...

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PMID: 15318941
DOI: 10.1186/bcr918

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