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Article

Repair of oxidized iron-sulfur clusters in Escherichia coli.

The Journal of biological chemistry - 22 Oct 2004

Djaman Ouliana, Outten F Wayne, Imlay James A

Abstract excerpt

The [4Fe-4S]2+ clusters of dehydratases are rapidly damaged by univalent oxidants, including hydrogen peroxide, superoxide, and peroxynitrite. The loss of an electron destabilizes the cluster, causing it to release its catalytic iron atom and converting the cluster initially to an inactive [3Fe-4S]1+ form. Continued exposure to oxidants in vitro leads to further iron release. Experiments have shown that these...

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Identifiers

PMID: 15308657
DOI: 10.1074/jbc.M406487200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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