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Article

Epstein‐Barr virus nuclear antigen 1 evades direct immune recognition by CD4<sup>+</sup> T helper cells

29 Jul 2004

Abstract excerpt

The Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is the only viral protein regularly expressed in EBV-associated malignancies. Immune recognition of EBNA1 by CD8+ T cells is prevented by an internal glycine-alanine repeat (GAr) which blocks proteasomal degradation. To test whether EBV-infected cells could be recognized by T helper cells, human CD4+ T cell clones specific for EBNA1 were isolated from...

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PMID: 15307182
DOI: 10.1002/eji.200324794

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