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Article

Mss51p and Cox14p jointly regulate mitochondrial Cox1p expression in Saccharomyces cerevisiae.

The EMBO journal - 1 Sept 2004

Barrientos Antoni, Zambrano Andrea, Tzagoloff Alexander

Abstract excerpt

Mutations in SURF1, the human homologue of yeast SHY1, are responsible for Leigh's syndrome, a neuropathy associated with cytochrome oxidase (COX) deficiency. Previous studies of the yeast model of this disease showed that mutant forms of Mss51p, a translational activator of COX1 mRNA, partially rescue the COX deficiency of shy1 mutants by restoring normal synthesis of the mitochondrially encoded Cox1p subunit of...

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Source

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Identifiers

PMID: 15306853
DOI: 10.1038/sj.emboj.7600358
PMCID: PMC516630

Genes

COX14
SURF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mss51p and Cox14p jointly regulate mitochondrial Cox1p expression in Saccharomyces cerevisiae.PMID 15306853Read ↗

Shy1p is necessary for full expression of mitochondrial COX1 in the yeast model of Leigh's syndrome.Semantic proximity Read ↗

Transcriptional activators HAP/NF-Y rescue a cytochrome c oxidase defect in yeast and human cells.Semantic proximity Read ↗

Adaptation of respiratory chain biogenesis to cytochrome c oxidase deficiency caused by SURF1 gene mutations.Semantic proximity Read ↗

Mss51p, a putative translational activator of cytochrome c oxidase subunit-1 (COX1) mRNA, is required for synthesis of Cox1p in Saccharomyces cerevisiae.Semantic proximity Read ↗

Aberrant translation of cytochrome c oxidase subunit 1 mRNA species in the absence of Mss51p in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Leigh syndrome in Drosophila melanogaster: morphological and biochemical characterization of Surf1 post-transcriptional silencing.Semantic proximity Read ↗

Mss51 and Ssc1 facilitate translational regulation of cytochrome c oxidase biogenesis.Semantic proximity Read ↗

SHY1, the yeast homolog of the mammalian SURF-1 gene, encodes a mitochondrial protein required for respiration.Semantic proximity Read ↗

The P174L mutation in human Sco1 severely compromises Cox17-dependent metallation but does not impair copper binding.Semantic proximity Read ↗

The MSS51 gene product is required for the translation of the COX1 mRNA in yeast mitochondria.Semantic proximity Read ↗

Hmo1, an HMG-box protein, belongs to the yeast ribosomal DNA transcription system.Semantic proximity Read ↗

Characterization of SURF-1 expression and Surf-1p function in normal and disease conditions.Semantic proximity Read ↗

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