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Article

Transcriptional activators HAP/NF-Y rescue a cytochrome c oxidase defect in yeast and human cells.

Human molecular genetics - 15 Mar 2008

Fontanesi Flavia, Jin Can, Tzagoloff Alexander, Barrientos Antoni

Abstract excerpt

Cell survival and energy production requires a functional mitochondrial respiratory chain. Biogenesis of cytochrome c oxidase (COX), the last enzyme of the mitochondrial respiratory chain, is a very complicated process and requires the assistance of a large number of accessory factors. Defects in COX assembly alter cellular respiration and produce severe human encephalomyopathies. Mutations in SURF1, a COX...

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Identifiers

PMID: 18045776
DOI: 10.1093/hmg/ddm349

Genes

SURF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Transcriptional activators HAP/NF-Y rescue a cytochrome c oxidase defect in yeast and human cells.PMID 18045776Read ↗

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