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Article

Nitric oxide facilitates cardiomyogenesis in mouse embryonic stem cells.

Proceedings of the National Academy of Sciences of the United States of America - 17 Aug 2004

Kanno Shinichi, Kim Peter K M, Sallam Karim, Lei Jing, Billiar Timothy R, Shears Larry L

Abstract excerpt

Stem cell therapy holds great promise for the replacement of damaged or dysfunctional myocardium. Nitric oxide (NO) has been shown to promote embryonic stem (ES) cell differentiation in other systems. We hypothesized that NO, through NO synthase gene transfer or exogenous NO exposure, would promote the differentiation of mouse ES cells into cardiomyocytes (CM). In our study, NO treatment increased both the number...

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Identifiers

PMID: 15304656
DOI: 10.1073/pnas.0401557101
PMCID: PMC514469

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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