Article
Characterization and Prevalence of MefA, MefE, and the Associated msr (D) Gene in Streptococcus pneumoniae Clinical Isolates
1 Aug 2004
Abstract excerpt
Recent work has shown that the efflux genes in Streptococcus pneumoniae that are responsible for acquired macrolide resistance can be distinguished as either mef(E) or mef(A). The genetic elements on which mef(A) and mef(E) are found also carry an open reading frame (ORF) that is 56% homologous to msr(A) in Staphylococcus. The prevalence of mef(A/E) and of the msr-like ORF [msr(D)] was evaluated in 153 mef(+) S....
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