Article
Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea.
Antimicrobial agents and chemotherapy - 1 Jul 2007
Shin Jeong Hwan, Jung Hee Jung, Kim Hye Ran, Jeong Joseph, Jeong Seok Hoon, Kim Sunjoo, Lee Eun Yup, Lee Jeong Nyeo, Chang Chulhun Ludgerus
Abstract excerpt
The genes erm(B), mef(A), and both erm(B) and mef(A) were identified in 42.6, 10.1, and 47.3%, respectively, of the erythromycin-resistant Streptococcus pneumoniae isolates. Of the strains, 3.8% were nonsusceptible to levofloxacin and had 1 to 6 amino acid changes in the quinolone resistance-determining region, including a new mutation, Asn94Ser, in the product of parC. Levofloxacin with reserpine was highly...
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