Article
Distribution of macrolide resistance genes erm(B) and mef(A) among 160 penicillin-intermediate clinical isolates of Streptococcus pneumoniae isolated in southern France.
Pathologie-biologie - 1 Sept 2001
Marchandin H, Jean-Pierre H, Jumas-Bilak E, Isson L, Drouillard B, Darbas H, Carrière C
Abstract excerpt
Two prevalent mechanisms of macrolide resistance are currently described in pneumococci: production of rRNA methylase that modify 23S ribosomal RNA resulting in MLSB phenotype, and an active efflux system resulting in M-phenotype. These two mechanisms are mediated by erm(B) and mef(A) genes respectively. Several studies reported a predominance of mef(A) gene in United-States and Canada. In European countries,...
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