Article
A promoter polymorphism of the CYP27B1 gene is associated with Addison's disease, Hashimoto's thyroiditis, Graves' disease and type 1 diabetes mellitus in Germans.
European journal of endocrinology - 1 Aug 2004
Lopez Elizabeth Ramos, Zwermann Oliver, Segni Maria, Meyer Gesine, Reincke Martin, Seissler Jochen, Herwig Jurgen, Usadel Klaus-H, Badenhoop Klaus
Abstract excerpt
BACKGROUND: CYP27B1 hydroxylase catalyzes the conversion of 25 hydroxyvitamin D(3) (25OHD(3)) to 1,25(OH)(2)D(3), the most active natural vitamin D metabolite, which plays a role in the regulation of immunity and cell proliferation. We therefore investigated two single nucleotide polymorphisms in the CYP27B1 hydroxylase gene for an association with Addison's disease, Hashimoto's thyroiditis, Graves' disease and...
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