Article
Primary pulmonary hypertension in children may have a different genetic background than in adults.
Pediatric research - 1 Oct 2004
Grünig Ekkehard, Koehler Rolf, Miltenberger-Miltenyi Gabriel, Zimmermann Rainer, Gorenflo Matthias, Mereles Derliz, Arnold Karlin, Naust Barbara, Wilkens Heinrike, Benz Andreas, von Hippel Albrecht, Ulmer Herbert E, Kübler Wolfgang, Katus Hugo A, Bartram Claus R, Schranz Dietmar, Janssen Bart
Abstract excerpt
Mutations of the bone morphogenetic protein receptor II (BMPR2) gene on chromosome 2q33 can cause familial primary pulmonary hypertension (PPH) and may occur in 26% adult patients with sporadic disease. Other disease-related genes have been localized to chromosomes 2q31 (PPH2) and 12q13 (ALK1). The genetic background in affected children remains unclear. Thirteen children (age at diagnosis, 6 mo to 13 y; mean,...
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