Article
SNPs in the promoter of a B cell-specific antisense transcript, SAS-ZFAT, determine susceptibility to autoimmune thyroid disease.
Human molecular genetics - 1 Oct 2004
Shirasawa Senji, Harada Haruhito, Furugaki Koichi, Akamizu Takashi, Ishikawa Naofumi, Ito Kunihiko, Ito Koichi, Tamai Hajime, Kuma Kanji, Kubota Sumihisa, Hiratani Hitomi, Tsuchiya Tomoko, Baba Iwai, Ishikawa Mayuko, Tanaka Masao, Sakai Kenji, Aoki Masayuki, Yamamoto Ken, Sasazuki Takehiko
Abstract excerpt
Autoimmune thyroid disease (AITD) is caused by an immune response to self-thyroid antigens and has a significant genetic component. Antisense RNA transcripts have been implicated in gene regulation. Here we have identified a novel zinc-finger gene, designated ZFAT (zinc-finger gene in AITD susceptibility region), as one of the susceptibility genes in 8q23-q24 through an initial association analysis using the...
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