HLA-A*0201-restricted cytolytic responses to the rtTA transactivator dominant and cryptic epitopes compromise transgene expression induced by the tetracycline on system.

doi:10.1016/j.ymthe.2004.05.012

Article

HLA-A*0201-restricted cytolytic responses to the rtTA transactivator dominant and cryptic epitopes compromise transgene expression induced by the tetracycline on system.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Aug 2004

Ginhoux F, Turbant S, Gross D A, Poupiot J, Marais T, Lone Y, Lemonnier F A, Firat H, Perez N, Danos O, Davoust J

Abstract excerpt

The tetracycline-controlled transcription system (Tet-on) is widely used to regulate gene expression in mammalian cells. In gene therapy applications, immune responses to Tet-on proteins such as the rtTA transcription factor have been reported, raising concerns about their occurrence in humans. To monitor the HLA class I cytolytic responses against Tet-on regulators, we characterized the immunogenic CD8+ epitopes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

HLA-A*0201-restricted cytolytic responses to the rtTA transactivator dominant and cryptic epitopes compromise transgene expression induced by the tetracycline on system.

Abstract excerpt

Topics

Related research