Article
Osteoprotegerin gene polymorphisms in men with coronary artery disease.
The Journal of clinical endocrinology and metabolism - 1 Aug 2004
Soufi Muhidien, Schoppet Michael, Sattler Alexander M, Herzum Matthias, Maisch Bernhard, Hofbauer Lorenz C, Schaefer Juergen R
Abstract excerpt
Osteoprotegerin (OPG) antagonizes receptor activator of nuclear factor-kappaB ligand (RANKL), the principal regulator of osteoclasts. Of note, OPG-deficient mice display osteoporosis and arterial calcification. Recently, OPG gene polymorphisms have been associated with osteoporosis and early predictors of cardiovascular disease. In this study, we examined OPG gene polymorphisms in 468 men who had absence of...
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