Article
Islet morphogenesis and stem cell markers.
Cell biochemistry and biophysics - 1 Jan 2004
Bouwens Luc
Abstract excerpt
The mechanism of islet neogenesis remains poorly understood, despite its potential applications in regenerative or replacement therapies for the treatment of insulin-dependent diabetes. During fetal development of the mouse or rat, the majority of islet cells are formed in late gestation (E18-21) by the process of neogenesis from precursor cells. The precursor cells are organized as ducts that actively...
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