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Article

Evolutionary genomics of ecological specialization.

Proceedings of the National Academy of Sciences of the United States of America - 10 Aug 2004

Zhong Shaobin, Khodursky Arkady, Dykhuizen Daniel E, Dean Antony M

Abstract excerpt

We used a combination of genomic techniques to monitor chromosomal evolution across hundreds of generations as Escherichia coli adapted to growth-limiting concentrations of either lactulose, methyl-galactoside, or a 72:28 mixture of the two. DNA microarrays identified 8 unique duplications and 16 unique deletions among 42 evolvants from 23 chemostat experiments. Each mutation was confirmed by sequencing...

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Identifiers

PMID: 15289609
DOI: 10.1073/pnas.0404397101
PMCID: PMC511043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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