Article
Uncomplicated human obesity is associated with a specific cardiac transcriptome: involvement of the Wnt pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2004
Philip-Couderc Pierre, Pathak Atul, Smih Fatima, Dambrin Camille, Harmancey Romain, Buys Sophie, Galinier Michel, Massabuau Pierre, Roncalli Jerome, Senard Jean-Michel, Rouet Philippe
Abstract excerpt
A dramatic increase in obesity prevalence and cardiovascular morbidity is expected for the coming years. However, with relevance to the heart, little is known about the specific contribution of obesity on associated morbidity. Consequently, global analysis of gene regulations in human heart was undertaken to monitor molecular regulations related to obesity or to obesity-related hypertension. Transcriptome...
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