Article
Mutation creates an open reading frame within the 5' untranslated region of macaque erythrocyte carbonic anhydrase (CA) I mRNA that suppresses CA I expression and supports the scanning model for translation.
Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 1992
Bergenhem N C, Venta P J, Hopkins P J, Kim H J, Tashian R E
Abstract excerpt
A variant allele at the CA I locus that produces a deficiency of erythrocyte-specific CA I occurs as a widespread polymorphism in pigtail macaques from southeast Asia. Sequence analyses revealed a C----G substitution 12 nucleotides downstream of the cap site in the variant erythrocyte CA I mRNA. This mutation forms a new AUG start site and an open reading frame coding for 26 amino acids that terminates 6...
Topics
- Animals
- Base Sequence
- Carbonic Anhydrases
- Gene Expression Regulation
- Macaca nemestrina
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Open Reading Frames
- Promoter Regions, Genetic