A donor splice mutation and a single-base deletion produce two carboxyl-terminal variants of human serum albumin.

doi:10.1073/pnas.88.14.5959

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Article

A donor splice mutation and a single-base deletion produce two carboxyl-terminal variants of human serum albumin.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 1991

Watkins S, Madison J, Davis E, Sakamoto Y, Galliano M, Minchiotti L, Putnam F W

Abstract excerpt

At least 35 allelic variants of human serum albumin have been sequenced at the protein level. All except two COOH-terminal variants, Catania and Venezia, are readily explainable as single-point substitutions. The two chain-termination variants are clustered in certain locations in Italy and are found in numerous unrelated individuals. In order to correlate the protein change in these variants with the...

Topics

Amino Acid Sequence
Base Sequence
Blotting, Southern
Carboxypeptidase B
Carboxypeptidases
Chromosome Deletion
Cloning, Molecular
DNA
Exons
Genetic Variation
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Nucleic Acid Hybridization

Oligonucleotide Probes

Polymerase Chain Reaction

Protein Conformation

RNA Splicing

Source

Open in PubMed Open full text

Identifiers

PMID: 2068071
DOI: 10.1073/pnas.88.14.5959
PMCID: PMC52001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2068071-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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