Article
The Trypanosoma brucei reference strain TREU927/4 contains T. brucei rhodesiense-specific SRA sequences, but displays a distinct phenotype of relative resistance to human serum.
Molecular and biochemical parasitology - 1 May 2004
Vanhamme Luc, Renauld Hubert, Lecordier Laurence, Poelvoorde Philippe, Van Den Abbeele Jan, Pays Etienne
Abstract excerpt
The Trypanosoma brucei reference strain TREU927/4 exhibits some resistance to lysis by normal human serum (NHS), but this resistance is never complete even after selection. The genome of this strain contains a minimum of eight sequences related to the T. brucei rhodesiense-specific serum resistance-associated gene (SRA), which encodes a truncated variant surface glycoprotein (VSG) conferring full resistance to...
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