Article
The genetic basis of neonatal diabetes mellitus.
Pediatric endocrinology reviews : PER - 1 Dec 2006
Sperling Mark A
Abstract excerpt
Neonatal diabetes mellitus is a rare condition occurring within the first few months of life that can either be permanent or transient. Various genetic defects responsible for both permanent and transient neonatal diabetes have been identified. ATP-sensitive potassium (KATP) channels are key regulators of nutrient-induced insulin secretion in pancreatic beta cells. Activating mutations of the KATP channel, which...
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