Towards optimally multiplexed applications of universal arrays.

doi:10.1089/1066527041410373

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Towards optimally multiplexed applications of universal arrays.

Journal of computational biology : a journal of computational molecular cell biology - 1 Jan 2004

Ben-Dor Amir, Hartman Tzvika, Karp Richard M, Schwikowski Benno, Sharan Roded, Yakhini Zohar

Abstract excerpt

We study a design and optimization problem that occurs, for example, when single nucleotide polymorphisms (SNPs) are to be genotyped using a universal DNA tag array. The problem of optimizing the universal array to avoid disruptive cross-hybridization between universal components of the system was addressed in previous work. Cross-hybridization can, however, also occur assay specifically, due to unwanted...

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