Article
[From gene to disease; primary open-angle glaucoma and three known genes: MYOC, CYP1B1 and OPTN].
Nederlands tijdschrift voor geneeskunde - 3 Jul 2004
Bergen A A B, Leschot N J, Hulsman C A A, De Smet M D, De Jong P T V M
Abstract excerpt
Primary open-angle glaucoma (POAG) is a group of multifactorial diseases that affects 1.5% of the population. If untreated, the disease leads to irreversible damage to the visual system. The clinical features of POAG are excavation of the optic disc and visual field defects, probably due to degeneration of retinal ganglion cells. Important risk factors for POAG are older age, elevated intraocular pressure, the...
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