Article
Folate modulates Hox gene-controlled skeletal phenotypes.
Genesis (New York, N.Y. : 2000) - 1 Jul 2004
Kappen Claudia, Mello Maria Alice, Finnell Richard H, Salbaum J Michael
Abstract excerpt
Hox genes are well-known regulators of pattern formation and cell differentiation in the developing vertebrate skeleton. Although skeletal variations are not uncommon in humans few mutations in human HOX genes have been described. If such mutations are compatible with life, there may be physiological modifiers for the manifestation of Hox gene-controlled phenotypes, masking underlying mutations. Here we present...
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