Article
A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians.
Human molecular genetics - 1 Oct 2004
Ma Xiaowei, Bacci Simonetta, Mlynarski Wojciech, Gottardo Lucia, Soccio Teresa, Menzaghi Claudia, Iori Elisabetta, Lager Robert A, Shroff Adhir R, Gervino Ernest V, Nesto Richard W, Johnstone Michael T, Abumrad Nada A, Avogaro Angelo, Trischitta Vincenzo, Doria Alessandro
Abstract excerpt
CD36 is a class B scavenger receptor recognizing a variety of ligands including long-chain fatty acids and modified LDL. We investigated whether genetic variability at this locus is a determinant of free fatty acid (FFA) plasma levels and risk of coronary artery disease (CAD) in Caucasians. Typing of 21 polymorphic markers, evenly spanning the CD36 gene, revealed two linkage disequilibrium (LD) blocks that could...
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