Article
Interleukin-4 gene polymorphism is not involved in the risk of recurrent pregnancy loss.
American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Aug 2004
Saijo Yasuaki, Sata Fumihiro, Yamada Hideto, Konodo Tomoko, Kato Emi Hirayama, Kataoka Soromon, Shimada Shigeki, Morikawa Mamoru, Minakami Hisanori, Kishi Reiko
Abstract excerpt
PROBLEM: Enhanced secretion of type-2 T-helper (Th2) cytokine is a characteristic feature in normal physiological pregnancy. A study has demonstrated defective production of interleukine-4 (IL-4) and other Th2 cytokine in women with recurrent pregnancy loss (RPL). Several studies have suggested that IL-4 variable number of tandem repeat (VNTR) gene polymorphism is probably associated with different IL-4...
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