Article
Analysis of Sciellin (SCEL) as a candidate gene in esophageal squamous cell carcinoma.
Anticancer research - 1 Jan 2000
Corona Winston, Karkera Deepa J, Patterson Robert H, Saini Nirmal, Trachiotis Gregory D, Korman Louis Y, Liu Benita, Alexander Edmund P, De la Pena Arturo S, Marcelo Alvin B, Wadleigh Robert
Abstract excerpt
BACKGROUND: The aim of this study was to investigate whether a candidate gene, Sciellin (SCEL), mapping to the chromosome 13q21-q31 is mutated in esophageal cancer. MATERIALS AND METHODS: The coding region and intron-exon junctions of SCEL were sequenced in 13 esophageal squamous cell cancers and matching normal esophageal samples to detect mutations. RESULTS: Three single nucleotide polymorphisms were detected...
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