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Novel Phage Display-Based Subtractive Screening To Identify Vaccine Candidates of<i>Brugia malayi</i>

23 Jul 2004

Abstract excerpt

This study describes a novel phage display method based on an iterative subtraction strategy to identify candidate vaccine antigens of Brugia malayi. A cDNA library of the infective larval stage of B. malayi expressed on the surface of T7 phage was sequentially screened with sera samples from human subjects showing different manifestations of the disease. Antigens that selectively and specifically bind to immune...

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Identifiers

PMID: 15271932
DOI: 10.1128/iai.72.8.4707-4715.2004

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