Article
Influence of estrogen receptor variants in mammary carcinomas on the prognostic reliability of the receptor assay.
Molecular and cellular endocrinology - 1 May 1992
Sluyser M, Wittliff J L
Abstract excerpt
We have used GR mouse mammary carcinomas as a model for evaluating the effect of estrogen receptor (ER) variants, present in the tumor cytosols, on the prognostic reliability of the receptor assay. Rapid, high resolution procedures were used for the assessment of wild-type and variant estrogen receptors in the cytosols of hormone-responsive and nonresponsive mammary tumors of GR mice. Two main ER types were...
Topics
- Animals
- Antibodies, Monoclonal
- Chromatography, High Pressure Liquid
- Chromatography, Ion Exchange
- Cytosol
- Estradiol
- Female
- Genetic Variation
- Mammary Neoplasms, Experimental
- Mice
- Neoplasm Transplantation