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Article

Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product.

Cell - 18 Sept 1992

Seabra M C, Brown M S, Slaughter C A, Südhof T C, Goldstein J L

Abstract excerpt

Rab geranylgeranyl transferase (GG transferase) from rat brain contains two components, A and B. Component B comprises polypeptides of 60 and 38 kd. Here we report the purification of component A, a single 95 kd polypeptide. The holoenzyme attaches 3H-geranylgeranyl to cysteines in two GTP-binding proteins, Rab3A and Rab1A. The reaction is abolished when both cysteines in the COOH-terminal CysCys sequence of...

Topics

Alkyl and Aryl Transferases
Amino Acid Sequence
Animals
Base Sequence
Brain
Choroideremia
Chromatography, Liquid
Molecular Sequence Data
Mutation
Rats
Rats, Inbred Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Homology, Nucleic Acid

Transferases

Source

Identifiers

PMID: 1525821
DOI: 10.1016/0092-8674(92)90253-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1525821-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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