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Article

Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product.

Cell - 18 Sept 1992

Seabra M C, Brown M S, Slaughter C A, Südhof T C, Goldstein J L

Abstract excerpt

Rab geranylgeranyl transferase (GG transferase) from rat brain contains two components, A and B. Component B comprises polypeptides of 60 and 38 kd. Here we report the purification of component A, a single 95 kd polypeptide. The holoenzyme attaches 3H-geranylgeranyl to cysteines in two GTP-binding proteins, Rab3A and Rab1A. The reaction is abolished when both cysteines in the COOH-terminal CysCys sequence of...

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PMID: 1525821
DOI: 10.1016/0092-8674(92)90253-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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