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Article

Copy number variation at the breakpoint region of isochromosome 17q.

Genome research - 1 Nov 2008

Carvalho Claudia M B, Lupski James R

Abstract excerpt

Isochromosome 17q, or i(17q), is one of the most frequent nonrandom changes occurring in human neoplasia. Most of the i(17q) breakpoints cluster within a approximately 240-kb interval located in the Smith-Magenis syndrome common deletion region in 17p11.2. The breakpoint cluster region is characterized by a complex architecture with large ( approximately 38-49 kb), inverted and directly oriented, low-copy repeats...

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Share to Chromosome Breakage
Share to Chromosomes, Artificial, Bacterial
Share to Chromosomes, Human, Pair 17

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18714090
DOI: 10.1101/gr.080697.108
PMCID: PMC2577857

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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