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Article

BN80927

15 Jul 2004

Abstract excerpt

BN80927 belongs to a novel family of camptothecin analogs, the homocamptothecins, developed on the concept of topoisomerase I (Topo I) inhibition and characterized by a stable seven-membered beta-hydroxylactone ring. Preclinical data reported here show that BN80927 retains Topo I poisoning activity in cell-free assay (DNA relaxation) as well as in living cells, in which in vivo complexes of topoisomerase...

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Identifiers

PMID: 15256467
DOI: 10.1158/0008-5472.can-03-3872

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