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Article

The relationship of the human glutathione S-transferase P1 polymorphism and chemotherapeutic sensitivity in head and neck squamous carcinoma.

International journal of molecular medicine - 1 Aug 2004

Kimura Shinobu, Imagawa Yukari, Satake Kenichi, Tsukuda Mamoru

Abstract excerpt

GSTP1, which encodes GSTPi, has a polymorphic site at codon 105 (exon 5), where an adenosine-to-guanine (A-G) transition causes an isoleucine-to-valine substitution (I105V). Recent studies have found that subjects with the valine allele display a significantly lower enzyme activity and less effective capability of detoxification. We hypothesized that head and neck squamous cell carcinoma (HNSCC) might respond...

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Source

Identifiers

PMID: 15254763

Genes

GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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