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Article

Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells.

Cancer research - 15 Mar 2006

Mori Akio, Lehmann Sören, O'Kelly James, Kumagai Takashi, Desmond Julian C, Pervan Milena, McBride William H, Kizaki Masahiro, Koeffler H Phillip

Abstract excerpt

Capsaicin is the major pungent ingredient in red peppers. Here, we report that it has a profound antiproliferative effect on prostate cancer cells, inducing the apoptosis of both androgen receptor (AR)-positive (LNCaP) and -negative (PC-3, DU-145) prostate cancer cell lines associated with an increase of p53, p21, and Bax. Capsaicin down-regulated the expression of not only prostate-specific antigen (PSA) but...

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Identifiers

PMID: 16540674
DOI: 10.1158/0008-5472.CAN-05-0087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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