Article
A human t-PA mutant cDNA cassette knocked in the murine fgfr-4 locus targeting for mammary gland expression.
Acta biochimica et biophysica Sinica - 1 Jul 2004
Lin Fu-Yu, Chen Hong-Xing, Cheng Xuan, Xiao Yang, Deng Ji-Xian, Huang Pei-Tang
Abstract excerpt
The expression of foreign gene in transgenic animals produced by pronuclear microinjection is often confounded by the position effects caused by not only the nature of chromosomal integration site but also the number and arrangement of multiple transgene copies. Gene targeting provides a new way to overcome these inhibitions by introducing single-copy transgene into a chosen site. The choice of a good chromosomal...
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