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Article

Sacrococcygeal chordomas in patients with tuberous sclerosis complex show somatic loss of TSC1 or TSC2.

Genes, chromosomes & cancer - 1 Sept 2004

Lee-Jones Lisa, Aligianis Irene, Davies Peter A, Puga Ana, Farndon Peter A, Stemmer-Rachamimov Anat, Ramesh Vijaya, Sampson Julian R

Abstract excerpt

Chordomas are rare sacrococcygeal/sacral, sphenooccipital/clivus, and spinal tumors whose molecular etiology remains relatively understudied. As several anecdotal reports had described chordomas in individuals with tuberous sclerosis complex (TSC), a multisystem hamartoma syndrome, we hypothesized that the genes that cause TSC may have an etiological role in chordomas. In two cases of sacrococcygeal chordomas in...

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Source

Identifiers

PMID: 15236319
DOI: 10.1002/gcc.20052

Genes

TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sacrococcygeal chordomas in patients with tuberous sclerosis complex show somatic loss of TSC1 or TSC2.PMID 15236319Read ↗

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