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Article

Germline findings in cancer predisposing genes from a small cohort of chordoma patients.

Journal of cancer research and clinical oncology - 3 May 2024

Raygada Margarita, John Liny, Liu Anne, Schultz Julianne, Thomas B J, Bernstein Donna, Miettinen Markku, Raffeld Mark, Xi Liqiang, Tyagi Manoj, Aldape Kenneth, Glod John, Reilly Karlyne M, Widemann Brigitte C, Wedekind Mary Frances

Abstract excerpt

INTRODUCTION: Chordoma is a rare slow-growing tumor that occurs along the length of the spinal axis and arises from primitive notochordal remnants (Stepanek et al., Am J Med Genet 75:335-336, 1998). Most chordomas are sporadic, but a small percentage of cases are due to hereditary cancer syndromes (HCS) such as tuberous sclerosis 1 and 2 (TSC1/2), or constitutional variants in the gene encoding brachyury T (TBXT)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38700789
DOI: 10.1007/s00432-024-05706-5
PMCID: PMC11068663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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