Article
Frequency and nature of cytokine gene polymorphisms in hepatocellular carcinoma in Hong Kong Chinese.
International journal of gastrointestinal cancer - 1 Jan 2003
Heneghan Michael A, Johnson Philip J, Clare Michael, Ho Stephen, Harrison Phillip M, Donaldson Peter T
Abstract excerpt
BACKGROUND: The genetic basis of susceptibility to hepatocellular carcinoma (HCC) is poorly understood. Genomic DNA was available from 98 patients with HCC, 77 familial controls, 97 controls from Hong Kong and 96 Northern European controls (NECs). METHODS: Polymorphisms of interleukin (IL)-1beta; IL-1 receptor antagonist (IL-1RN); IL-10 promoter (positions -1082, -819, and -592); and tumor necrosis factor...
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