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Article

Tissue-specific cytochrome c oxidase assembly defects due to mutations in SCO2 and SURF1.

The Biochemical journal - 15 Dec 2005

Stiburek Lukas, Vesela Katerina, Hansikova Hana, Pecina Petr, Tesarova Marketa, Cerna Leona, Houstek Josef, Zeman Jiri

Abstract excerpt

The biogenesis of eukaryotic COX (cytochrome c oxidase) requires several accessory proteins in addition to structural subunits and prosthetic groups. We have analysed the assembly state of COX and SCO2 protein levels in various tissues of six patients with mutations in SCO2 and SURF1. SCO2 is a copper-binding protein presumably involved in formation of the Cu(A) centre of the COX2 subunit. The function of SURF1...

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Source

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Identifiers

PMID: 16083427
DOI: 10.1042/BJ20050807
PMCID: PMC1316303

Genes

SCO2
SURF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tissue-specific cytochrome c oxidase assembly defects due to mutations in SCO2 and SURF1.PMID 16083427Read ↗

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