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Article

A gene for speed? The evolution and function of alpha-actinin-3.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Jul 2004

MacArthur Daniel G, North Kathryn N

Abstract excerpt

The alpha-actinins are an ancient family of actin-binding proteins that play structural and regulatory roles in cytoskeletal organisation and muscle contraction. alpha-actinin-3 is the most-highly specialised of the four mammalian alpha-actinins, with its expression restricted largely to fast glycolytic fibres in skeletal muscle. Intriguingly, a significant proportion ( approximately 18%) of the human population...

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Source

Identifiers

PMID: 15221860
DOI: 10.1002/bies.20061

Genes

ACTN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An Actn3 knockout mouse provides mechanistic insights into the association between -actinin-3 deficiency and human athletic performanceSemantic proximity Read ↗

The Effect of Heterozygosity for the ACTN3 Null Allele on Human Muscle Performance.Semantic proximity Read ↗

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