Article
PSC-RANTES blocks R5 human immunodeficiency virus infection of Langerhans cells isolated from individuals with a variety of CCR5 diplotypes.
Journal of virology - 1 Jul 2004
Kawamura Tatsuyoshi, Bruse Shannon E, Abraha Awet, Sugaya Makoto, Hartley Oliver, Offord Robin E, Arts Eric J, Zimmerman Peter A, Blauvelt Andrew, Bruce Shannon E
Abstract excerpt
Topical microbicides that effectively block interactions between CCR5(+) immature Langerhans cells (LC) residing within genital epithelia and R5 human immunodeficiency virus (HIV) may decrease sexual transmission of HIV. Here, we investigated the ability of synthetic RANTES analogues (AOP-, NNY-, and PSC-RANTES) to block R5 HIV infection of human immature LC by using a skin explant model. In initial experiments...
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